A study of ancient literature indicates that hyperlipidemia was fairly well known and well conceived as an entity in India. The modern medicines are very efficient in curing diseases but they are produces a number of side effects, on the contrary, the crude drugs are some what less efficient than modern medicines but they are relatively free from side effects which made the traditional system of medicine to create the competition to modern day medicine. Hence, the present study aims to open new avenues for the improvement of herbal drugs. For the area for Hyperlipidemia Polyalthia longifolia is a lofty evergreen tree, native to India, commonly known as “Green Champa” and planted due to its effectiveness in alleviating noise pollution. It exhibits symmetrical pyramidal growth with willowy weeping pendulous branches and long narrow lanceolate leaves with undulate margins. Polyalthia longifolia is sometimes incorrectly identified as Ashoka tree (Saraca Indica) because of very close resemblance of both. Study is to bring the anti-hyperlipidemic medicinal plants sector on a firm scientific footing, raise awareness and add value to the resource. Ethanol and aqueous (60-80°C) extracts of leaves of Polyalthia longifolia where subjected for anti-lipidemic activity in New Zealand rabbits (1.5-3.5 kg). Serum lipid level was determined using kits. The oral administration of leaf extracts at doses of 150 mg/ kg− lead to a significant blood lipid reduction. This laid the foundation to study the active compounds of such anti-lipidemia plants that are responsible for the hypolipidemic activities.
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